化学
甲酰胺类
试剂
激进的
组合化学
催化作用
串联
氢原子
有机化学
复合材料
材料科学
烷基
作者
Hong He,Qinhui Wan,Zhong‐Wei Hou,Quan Zhou,Lei Wang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-09-18
卷期号:25 (38): 7014-7019
被引量:49
标识
DOI:10.1021/acs.orglett.3c02607
摘要
Organoelectrophotocatalytic generation of acyl radicals from formamides and aldehydes to synthesize acylated 3-CF3-2-oxindoles has been developed. This protocol features a monocatalytic system using 9,10-phenanthrenequinone (PQ) both as a catalyst and as a hydrogen atom transfer (HAT) reagent, which avoids the use of an external HAT reagent, metal reagent, and oxidant. A variety of acylated 3-CF3-2-oxindoles have been obtained in satisfactory yields from CF3-substituted N-arylacrylamides via a tandem radical cyclization.
科研通智能强力驱动
Strongly Powered by AbleSci AI