Artemisinin alleviates obesity‐related glomerulopathy by downregulating CYP24A1 expression

Diabetes, Obesity and MetabolismEarly View RESEARCH LETTER Artemisinin alleviates obesity-related glomerulopathy by downregulating CYP24A1 expression Xiaorong Chen MS, Xiaorong Chen MS orcid.org/0000-0001-6769-8843 Medical College, Southwest Jiaotong University, Chengdu, China Department of General Medicine, Chengdu Second People's Hospital, Chengdu, ChinaSearch for more papers by this authorJie Xiang MS, Jie Xiang MS orcid.org/0009-0005-8439-4928 Medical College, Southwest Jiaotong University, Chengdu, China Department of General Medicine, Chengdu Second People's Hospital, Chengdu, ChinaSearch for more papers by this authorPeng Gao PhD, Peng Gao PhD Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, ChinaSearch for more papers by this authorLijuan Wang BS, Lijuan Wang BS Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, ChinaSearch for more papers by this authorLi Xiang BS, Li Xiang BS Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaSearch for more papers by this authorZongshi Lu MD, Zongshi Lu MD Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, ChinaSearch for more papers by this authorTingbing Cao BS, Tingbing Cao BS Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, ChinaSearch for more papers by this authorAidi Mou BS, Aidi Mou BS Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, ChinaSearch for more papers by this authorXingping Zhang PhD, Xingping Zhang PhD Department of General Medicine, Chengdu Second People's Hospital, Chengdu, ChinaSearch for more papers by this authorXiaoyan Jiang PhD, Xiaoyan Jiang PhD Department of Endocrinology and Metabolism, Chongqing Emergency Medical Centre, Chongqing University Central Hospital, Chongqing, ChinaSearch for more papers by this authorZhiming Zhu MD, PhD, Corresponding Author Zhiming Zhu MD, PhD hbpcms@sina.com orcid.org/0000-0001-6297-2962 Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, China Correspondence Zhiming Zhu, Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, 400000, China. Email: hbpcms@sina.com Hongmei Lang, Medical College, Southwest Jiaotong University, Chengdu, Sichuan 610031, China. Email: junialang@sina.comSearch for more papers by this authorHongmei Lang MD, Corresponding Author Hongmei Lang MD junialang@sina.com Department of General Medicine, Chengdu Second People's Hospital, Chengdu, China Correspondence Zhiming Zhu, Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, 400000, China. Email: hbpcms@sina.com Hongmei Lang, Medical College, Southwest Jiaotong University, Chengdu, Sichuan 610031, China. Email: junialang@sina.comSearch for more papers by this author Xiaorong Chen MS, Xiaorong Chen MS orcid.org/0000-0001-6769-8843 Medical College, Southwest Jiaotong University, Chengdu, China Department of General Medicine, Chengdu Second People's Hospital, Chengdu, ChinaSearch for more papers by this authorJie Xiang MS, Jie Xiang MS orcid.org/0009-0005-8439-4928 Medical College, Southwest Jiaotong University, Chengdu, China Department of General Medicine, Chengdu Second People's Hospital, Chengdu, ChinaSearch for more papers by this authorPeng Gao PhD, Peng Gao PhD Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, ChinaSearch for more papers by this authorLijuan Wang BS, Lijuan Wang BS Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, ChinaSearch for more papers by this authorLi Xiang BS, Li Xiang BS Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaSearch for more papers by this authorZongshi Lu MD, Zongshi Lu MD Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, ChinaSearch for more papers by this authorTingbing Cao BS, Tingbing Cao BS Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, ChinaSearch for more papers by this authorAidi Mou BS, Aidi Mou BS Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, ChinaSearch for more papers by this authorXingping Zhang PhD, Xingping Zhang PhD Department of General Medicine, Chengdu Second People's Hospital, Chengdu, ChinaSearch for more papers by this authorXiaoyan Jiang PhD, Xiaoyan Jiang PhD Department of Endocrinology and Metabolism, Chongqing Emergency Medical Centre, Chongqing University Central Hospital, Chongqing, ChinaSearch for more papers by this authorZhiming Zhu MD, PhD, Corresponding Author Zhiming Zhu MD, PhD hbpcms@sina.com orcid.org/0000-0001-6297-2962 Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, China Correspondence Zhiming Zhu, Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, 400000, China. Email: hbpcms@sina.com Hongmei Lang, Medical College, Southwest Jiaotong University, Chengdu, Sichuan 610031, China. Email: junialang@sina.comSearch for more papers by this authorHongmei Lang MD, Corresponding Author Hongmei Lang MD junialang@sina.com Department of General Medicine, Chengdu Second People's Hospital, Chengdu, China Correspondence Zhiming Zhu, Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, and Chongqing Institute of Hypertension, Chongqing, 400000, China. Email: hbpcms@sina.com Hongmei Lang, Medical College, Southwest Jiaotong University, Chengdu, Sichuan 610031, China. Email: junialang@sina.comSearch for more papers by this author First published: 03 November 2023 https://doi.org/10.1111/dom.15355 Xiaorong Chen and Jie Xiang should be considered joint first authors. Hongmei Lang is the lead contact. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat CONFLICT OF INTEREST STATEMENT The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. Open Research PEER REVIEW The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/dom.15355. DATA AVAILABILITY STATEMENT All the data in this study are available upon reasonable request from the corresponding author. Supporting Information Filename Description dom15355-sup-0001-Supinfo.docxWord 2007 document , 1.3 MB DATA S1. Supporting Information. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. REFERENCES 1Kambham N, Markowitz GS, Valeri AM, Lin J, D'Agati VD. Obesity-related glomerulopathy: an emerging epidemic. Kidney Int. 2001; 59: 1498-1509. 10.1046/j.1523-1755.2001.0590041498.x CASPubMedWeb of Science®Google Scholar 2Hsu CY, McCulloch CE, Iribarren C, Darbinian J, Go AS. Body mass index and risk for end-stage renal disease. Ann Intern Med. 2006; 144: 21-28. 10.7326/0003-4819-144-1-200601030-00006 CASPubMedWeb of Science®Google Scholar 3Greka A, Mundel P. Cell biology and pathology of podocytes. 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