神经退行性变
氧化应激
疾病
医学
阿尔茨海默病
淀粉样蛋白(真菌学)
细胞内
病态的
细胞外
τ蛋白
抗氧化剂
病理
生物
内科学
生物化学
作者
Pravat K. Mandal,Joseph C. Maroon,Arun Garg,Narendra K. Arora,R.K. Bansal,Aditi Kaushik,Avantika Samkaria,G. Senthil Kumaran,Yashika Arora
标识
DOI:10.1021/acschemneuro.3c00641
摘要
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that affects millions of people worldwide. The characteristic pathological manifestation of AD includes the deposition of extracellular insoluble β amyloid plaques and intracellular neurofibrillary tangles formed from hyperphosphorylated tau protein. Cost effective and minimally invasive peripheral blood-based biomarkers are critical for early AD diagnosis. Currently, the plasma based two fraction of β amyloid peptide ratio (Aβ42/40) and phosphorylated tau (p-tau) are considered as blood-based biomarkers for AD diagnosis. Recent research indicates that oxidative stress (OS) occurs prior to amyloid plaque (Aβ) formation and abnormal tau phosphorylation in AD. The imbalance of the master antioxidant, glutathione (GSH), and prooxidants (iron, zinc, and copper)─plays a crucial role in AD neurodegeneration. We present peripheral blood-based OS related biomarkers that are mechanistically involved in the disease process and may serve as a novel screening tool for early detection of AD onset. This OS based approach may also provide a quick and cost efficient method to monitor the effects of disease-modifying therapies in AD clinical trials.
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