Hydrogels and hydrogel-based drug delivery systems for promoting refractory wound healing: Applications and prospects

Refractory wounds represent a significant health concern that presents considerable challenges within clinical practice. The healing process of refractory wounds, which involves various cell types and biologically active molecules, is dynamically influenced by multiple factors, including diabetes, infections, and inflammation. Owing to their hydrophilicity, biocompatibility, and capacity for drug loading, hydrogels have emerged as promising and innovative biomaterials for enhancing wound healing. In recent decades, hydrogels with inherent therapeutic properties have been identified. Moreover, advanced hydrogel-based drug delivery systems have been developed to facilitate the sustained and controlled release of therapeutic agents at the site of refractory wounds. This review aims to summarize recent advancements and applications of hydrogels, including those with intrinsic therapeutic properties and hydrogel-based drug delivery systems, in the treatment of refractory wounds. Additionally, we discuss the limitations associated with hydrogel applications and propose future perspectives, which will lead to ongoing efforts to optimize hydrogels as ideal biomaterials for refractory wound healing.