旁分泌信号
血管生成
平衡
收缩性
再生(生物学)
自分泌信号
医学
心脏毒性
缺血
疾病
内皮干细胞
生物
细胞生物学
内科学
受体
化疗
生物化学
体外
作者
D. Adao,Crizza Ching,Jason E. Fish,Craig A. Simmons,Filio Billia
出处
期刊:Clinical Science
[Portland Press]
日期:2024-11-01
卷期号:138 (21): 1395-1419
摘要
Abstract To maintain homeostasis in the heart, endothelial cells and cardiomyocytes engage in dynamic cross-talk through paracrine signals that regulate both cardiac development and function. Here, we review the paracrine signals that endothelial cells release to regulate cardiomyocyte growth, hypertrophy and contractility, and the factors that cardiomyocytes release to influence angiogenesis and vascular tone. Dysregulated communication between these cell types can drive pathophysiology of disease, as seen in ischemia-reperfusion injury, diabetes, maladaptive hypertrophy, and chemotherapy-induced cardiotoxicity. Investigating the role of cross-talk is critical in developing an understanding of tissue homeostasis, regeneration, and disease pathogenesis, with the potential to identify novel targets for diagnostic and therapeutic purposes.
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