河马信号通路
生物
癌症研究
转录因子
癌变
抑制器
效应器
肿瘤微环境
表观遗传学
细胞生物学
癌症
肿瘤细胞
遗传学
基因
作者
Reza Bayat Mokhtari,Neda Ashayeri,Leili Baghaie,Manpreet Sambi,Kosar Satari,Narges Baluch,Dmitriy A. Bosykh,Myron R. Szewczuk,Sayan Chakraborty
出处
期刊:Cancers
[MDPI AG]
日期:2023-07-02
卷期号:15 (13): 3468-3468
被引量:21
标识
DOI:10.3390/cancers15133468
摘要
Various cancer cell-associated intrinsic and extrinsic inputs act on YAP/TAZ proteins to mediate the hyperactivation of the TEAD transcription factor-based transcriptome. This YAP/TAZ-TEAD activity can override the growth-limiting Hippo tumor-suppressor pathway that maintains normal tissue homeostasis. Herein, we provide an integrated summary of the contrasting roles of YAP/TAZ during normal tissue homeostasis versus tumor initiation and progression. In addition to upstream factors that regulate YAP/TAZ in the TME, critical insights on the emerging functions of YAP/TAZ in immune suppression and abnormal vasculature development during tumorigenesis are illustrated. Lastly, we discuss the current methods that intervene with the YAP/TAZ-TEAD oncogenic signaling pathway and the emerging applications of combination therapies, gut microbiota, and epigenetic plasticity that could potentiate the efficacy of chemo/immunotherapy as improved cancer therapeutic strategies.
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