Analyses of PTEN gene aberrations and evaluation of the therapeutic potential of mTOR inhibitor in HPV negative cervical carcinoma

Objective: We set out to analyze the gene aberrations of phosphatase and tensin homolog (PTEN) in HPV-negative cervical carcinoma, and to identify the gene dysregulation in PI3K-AKT-mTOR pathway from The Cancer Genome Atlas (TCGA) dataset compared to HPV-positive cervical carcinoma. It remained to be determined whether HPV-negative cervical carcinoma with PTEN gene aberrations could be a candidate for treatment with mTOR inhibitors.