化学
酰化
脂质A
糖基化
保护组
磷酸化
乙醚
立体化学
组合化学
有机化学
生物化学
催化作用
脂多糖
医学
内分泌学
烷基
作者
Cheng‐Kai Zhou,Zhuojia Xu,Gen Li,Qi Gao,Qiang Sui,Tiehai Li
标识
DOI:10.1080/07328303.2021.2016793
摘要
An efficient approach for the facile synthesis of a potent vaccine adjuvant RC-529 is described. The synthetic strategy relies on the flexible use of orthogonal protecting groups, which makes it possible to accomplish selective phosphorylation, glycosylation and acylation, respectively. In addition, the use of readily cleaved 2-naphthylmethyl (Nap) ether and allyl esters as permanent protecting groups greatly facilitates the final global deprotection steps to obtain pure RC-529. This work will contribute to the synthesis of lipid A and its derivatives.
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