[Relationship between chronic constipation and brain-gut microflora axis].

The role of the brain-gut microbiota axis in functional gastrointestinal diseases has been gradually recognized. According to the ROME IV diagnostic criteria, functional gastrointestinal diseases are classified as diseases caused by abnormal brain-gut interaction. This concept is of great significance to the change of diagnosis and treatment paradigm of functional gastrointestinal diseases. Chronic constipation is the most common functional gastrointestinal disease. The pathogenesis of chronic constipation is closely related to the imbalance of intestinal flora, the abnormality of enteric nervous system and neurotransmitter in brain. Therefore, in the diagnosis and treatment of chronic constipation, enough attention should be paid to the concept of integration of brain-gut microflora axis, but the clinical application of brain-gut microflora axis is still limited. This may be one of the factors for high incidence but poor treatment efficacy of chronic constipation. Based on the global research progress and our clinical experience, this article expounds the clinical significance of the brain-gut microbiota axis in chronic constipation.脑肠菌群轴在功能性胃肠疾病中的作用逐渐受到关注，根据罗马便秘Ⅳ诊断标准，将功能性胃肠疾病归类于脑肠功能互动异常，该概念的提出对功能性胃肠疾病诊疗模式的改变具有重要意义。慢性便秘是最为常见的功能性胃肠疾病之一，其发病机制与肠道菌群失衡、肠神经系统及脑神经递质异常密切相关，且互为因果，恶性循环。因此，在慢性便秘的诊疗中，脑肠菌群轴的整合理念应该得到足够的重视，国内外对于脑肠菌群轴的临床应用较为局限，这可能是慢性便秘虽然发病率高，但临床疗效欠佳的因素之一。本文根据国内外研究进展和作者临床经验，就脑肠菌群轴在慢性便秘的临床意义进行阐述。.