Increasing environmental and sustainability considerations have led to the revival of natural dyes. Even though the application of natural dyes on natural substrates has been extensively investigated, research regarding simultaneous dyeing, patterning and functional finishing of polyamide fabrics is reported to a limited extent. This paper aims at obtaining colored patterns on polyamide fabrics by laser pretreatment and dyeing with pomegranate peel dye. The most notable color difference can be obtained by using a 12 W laser and 2% (on weight of the fabric) pomegranate peel dye. The significant color difference between laser pretreated and untreated areas showed the pattern. It was then used for the further pattern design of polyamide fabrics combined with computer-aided design software. The dyed fabric had good color fastness, and no mordant was used in the dyeing process. In addition, the dyed fabrics were endowed with various functional properties by pomegranate peel dye.