医学
流体衰减反转恢复
松弛法
高强度
急性中风
病变
冲程(发动机)
放射科
磁共振成像
磁共振弥散成像
白质
核医学
成像生物标志物
病理
内科学
机械工程
自旋回波
组织纤溶酶原激活剂
工程类
作者
Joachim André,Sami Barrit,Patrice Jissendi
标识
DOI:10.1038/s41598-022-15204-8
摘要
Abstract Synthetic MR provides qualitative and quantitative multi-parametric data about tissue properties in a single acquisition. Its use in stroke imaging is not yet established. We compared synthetic and conventional image quality and studied synthetic relaxometry of acute and chronic ischemic lesions to investigate its interest for stroke imaging. We prospectively acquired synthetic and conventional brain MR of 43 consecutive adult patients with suspected stroke. We studied a total of 136 lesions, of which 46 DWI-positive with restricted ADC (DWI + /rADC), 90 white matter T2/FLAIR hyperintensities (WMH) showing no diffusion restriction, and 430 normal brain regions (NBR). We assessed image quality for lesion definition according to a 3-level score by two readers of different experiences. We compared relaxometry of lesions and regions of interest. Synthetic images were superior to their paired conventional images for lesion definition except for sFLAIR (sT1 or sPSIR vs. cT1 and sT2 vs. cT2 for DWI + /rADC and WMH definition; p values < .001) with substantial to almost perfect inter-rater reliability (κ ranging from 0.711 to 0.932, p values < .001). We found significant differences in relaxometry between lesions and NBR and between acute and chronic lesions (T1, T2, and PD of DWI + /rADC or WMH vs. mirror NBR; p values < .001; T1 and PD of DWI + /rADC vs. WMH; p values of 0.034 and 0.008). Synthetic MR may contribute to stroke imaging by fast generating accessible weighted images for visual inspection derived from rapidly acquired relaxometry data. Moreover, this synthetic relaxometry could differentiate acute and chronic ischemic lesions.
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