Sex-related association of nonalcoholic fatty liver disease and liver fibrosis with body fat distribution in the general US population

非酒精性脂肪肝 脂肪变性 内科学 优势比 瞬态弹性成像 脂肪肝 人口 胃肠病学 体质指数 医学 纤维化 内分泌学 肝纤维化 疾病 环境卫生
作者
Stefano Ciardullo,Alice Oltolini,Rosa Cannistraci,Emanuele Muraca,Gianluca Perseghin
出处
期刊:The American Journal of Clinical Nutrition [Elsevier BV]
卷期号:115 (6): 1528-1534 被引量:41
标识
DOI:10.1093/ajcn/nqac059
摘要

Few population-based studies have investigated the association between body fat distribution and the risk of nonalcoholic fatty liver disease (NAFLD) and significant liver fibrosis. We aimed to evaluate the relations of total body fat and body fat distribution with NAFLD in the general US population. This is a cross-sectional, population-based study based on the 2017–2018 cycle of the NHANES. Participants aged 18–59 y without known liver conditions or significant alcohol consumption were studied by DXA and vibration-controlled transient elastography to assess body composition and liver steatosis and fibrosis, respectively. Multivariable logistic regression analysis was performed to evaluate the contribution of BMI and android:gynoid ratio (A:G ratio) to the prevalence of liver steatosis and fibrosis in males and females. Weighted prevalence of steatosis was 41.5% and 29.9% among the 1115 males and 1113 females included in the study, respectively, whereas 7.0% of males and 4.0% of females had elastographic evidence of significant liver fibrosis. After adjustment for age, race-Hispanic origin, diabetes, cigarette smoke, and BMI, a higher A:G ratio was associated with increased odds of steatosis in both males (OR: 1.79; 95% CI: 1.07, 2.99; P = 0.029) and females (OR: 1.95; 95% CI: 1.11, 3.41; P = 0.023). Conversely, a significant association between A:G ratio and liver fibrosis was identified in females (OR: 2.09; 95% CI: 1.11, 3.97; P = 0.026), but not in males (OR: 0.56; 95% CI: 0.29, 1.08; P = 0.078). Independently from BMI, an android fat deposition pattern is associated with increased prevalence of NAFLD in both sexes, whereas the effect on fibrosis was only evident in females.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
A徽完成签到,获得积分10
刚刚
甜甜千兰完成签到,获得积分10
刚刚
Starry发布了新的文献求助10
刚刚
凶狠的谷蓝完成签到,获得积分10
刚刚
LIU完成签到,获得积分10
刚刚
1秒前
Renesmee发布了新的文献求助10
1秒前
Hancock完成签到 ,获得积分10
2秒前
AbA完成签到,获得积分10
2秒前
梅红完成签到,获得积分10
2秒前
正直从阳完成签到,获得积分10
3秒前
gao发布了新的文献求助10
3秒前
3秒前
缥缈梦柏完成签到,获得积分10
4秒前
4秒前
4秒前
马不停蹄完成签到,获得积分10
4秒前
AHR发布了新的文献求助10
4秒前
柠檬味的水完成签到,获得积分10
4秒前
天道酬勤完成签到,获得积分10
5秒前
爱吃鸡蛋的元德完成签到,获得积分10
5秒前
小幸运完成签到,获得积分10
5秒前
6秒前
shifeng发布了新的文献求助10
6秒前
善学以致用应助典雅的静采纳,获得10
6秒前
xzyin完成签到,获得积分10
6秒前
AI发布了新的文献求助10
7秒前
无奈若雁完成签到,获得积分10
7秒前
RJ完成签到,获得积分10
8秒前
8秒前
八里完成签到,获得积分10
8秒前
大鹏完成签到,获得积分10
8秒前
可靠半青完成签到 ,获得积分10
8秒前
A徽发布了新的文献求助10
8秒前
袁钰琳完成签到 ,获得积分10
9秒前
9秒前
关显锋发布了新的文献求助10
9秒前
屎味烤地瓜完成签到,获得积分10
9秒前
10秒前
景代丝发布了新的文献求助10
10秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968771
求助须知:如何正确求助?哪些是违规求助? 3513729
关于积分的说明 11169450
捐赠科研通 3249084
什么是DOI,文献DOI怎么找? 1794592
邀请新用户注册赠送积分活动 875258
科研通“疑难数据库(出版商)”最低求助积分说明 804740