Severe Airflow Obstruction From Constrictive (Obliterative) Bronchiolitis in Paraneoplastic Autoimmune Multiorgan Syndrome

Paraneoplastic autoimmune multiorgan syndrome (PAMS), also known as “paraneoplastic pemphigus,” is a rare life-threatening autoimmune disease triggered by an underlying neoplasm. It is characterized by painful erosive stomatitis and a polymorphous mucocutaneous eruption.1 A subset of patients with PAMS manifest pulmonary involvement characterized by progressive airflow obstruction related to constrictive (obliterative) bronchiolitis (also known as bronchiolitis obliterans).2