Exploring the potential antidepressant mechanisms of puerarin: Anti-inflammatory response via the gut-brain axis

葛根素 肠道菌群 行为绝望测验 抗抑郁药 开阔地 肠-脑轴 药理学 脑源性神经营养因子 神经营养因子 医学 内科学 免疫学 海马体 病理 受体 替代医学
作者
Xujiao Song,Weihao Wang,Shanshan Ding,Yan Wang,Lufen Ye,Xin Chen,Hao Ma
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:310: 459-471 被引量:28
标识
DOI:10.1016/j.jad.2022.05.044
摘要

Puerarin has been shown to have a good antidepressant effect, and our previous study found that it can remedy stress-induced dysbiosis. However, its gut microbiota-related mechanism has not been fully elucidated. Therefore, this study aimed to investigate the potential link between puerarin on gut microbiota and inflammatory responses in depressed rats.A chronic unpredictable mild stress (CUMS) rat model of depression was established, open field test (OFT), sucrose preference test (SPT) and forced swimming test (FST) were used to evaluate its antidepressant effect. 16S rRNA sequencing was performed to identify the rat fecal microflora. At the same time, inflammatory cytokines, colonic histopathological changes, and brain-derived neurotrophic factor (BDNF), nuclear factor kappa-B (NF-κB), inhibitor a of NF-κB (IκB-α) protein expression were detected.Puerarin attenuated CUMS-induced depressive-like behavior and gut microbiota dysregulation in rats, significantly reducing the abundance of harmful bacteria such as Desulfovibrio, Verrucomicrobiae, and Verrucomicrobia. In addition, puerarin can also reduce the pro-inflammatory factors and increase the level of anti-inflammatory factors in depressed rats, improve the damaged colon tissue, enhance the expression of BDNF and IκB-α in the hippocampus and inhibit the expression of NF-κB.Direct evidence that puerarin improves depressive-like behaviors via gut microbiota is lacking.The underlying mechanism of puerarin's antidepressant-like effect is closely related to the bidirectional communication of the microbiota-gut-brain axis by regulating the inflammatory response.
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