表观遗传学
高雄激素血症
生物信息学
DNA甲基化
胰岛素抵抗
内分泌系统
不育
医学
代谢综合征
生物
内科学
内分泌学
胰岛素
多囊卵巢
肥胖
激素
怀孕
遗传学
基因
基因表达
作者
В. В. Смирнов,Narasimha M. Beeraka,D. Yu. Butko,Vladimir N. Nikolenko,Sergey Bondarev,Е. Е. Ачкасов,Mikhail Y. Sinelnikov,P. R. Hemanth Vikram
标识
DOI:10.1007/s43032-022-01013-x
摘要
Polycystic ovarian syndrome (PCOS) can cause infertility in females due to hyperandrogenism and neuroendocrine abnormalities. The aim of this study is to decipher the impact of endocrine variables, hyperandogenism, insulin resistance, oxidative stress, and dietary conditions in PCOS conditions, subsequently to depict the role of epigenetic factors relative to phenotypic manifestations in PCOS conditions. We have reviewed several metabolic milieus pertinent to PCOS conditions. Comparative efficacies of various PCOS therapies, and recent clinical recommendations for the effective management of PCOS and role of metabolic/endocrine variables in PCOS conditions were described. Comparative therapeutic effects were vividly delineated according to the variable pathophysiology and internal variables during PCOS syndrome on the female body through the formation of cascade of endocrine pathology, which affects working capacity and fosters redox stress-induced cardiovascular, neural, and liver abnormalities. GLP-1 agonists, insulin sensitizers (metformin), and diet and exercise regimens efficacy were explained in enhancing the fertility outcomes among the overweight or obese females with PCOS. Comprehensive appraisal of DNA methylation as epigenetic changes and the manifestations of methylated genes in PCOS conditions were discussed particularly to screen novel molecular targets for developing efficient diagnostic indicators for predicting PCOS risk or its progression. Due to the reversible nature of epigenetic modifications, it is possible to screen the “druggable” regions to target or to correct abnormalities in the gene expression subsequently to develop chromatin-modifying therapies against PCOS.
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