下调和上调
大流行
免疫学
疾病
跨膜蛋白
病毒学
冠状病毒
生物
干扰素
医学
2019年冠状病毒病(COVID-19)
基因
内科学
遗传学
传染病(医学专业)
受体
作者
Nora E. Regino-Zamarripa,Gustavo Ramírez-Martínez,Luis Armando Jiménez-Álvarez,Alfredo Cruz‐Lagunas,Itzel Alejandra Gómez-García,Sergio Ignacio-Cortés,José Eduardo Márquez-García,Lynette Miroslava Pacheco-Hernández,Jazmín Ariadna Ramírez-Noyola,Rodrigo Barquera,Criselda Mendoza-Milla,César Luna-Rivero,Guillermo Domínguez‐Cherit,Remedios Ramírez-Rangel,Tatiana Sofia Rodrı́guez-Reyna,Carmen Margarita Hernández‐Cardenas,José Alberto Choreño-Parra,Gloria León-Ávila,Joaquı́n Zúñiga
出处
期刊:Journal of Interferon and Cytokine Research
[Mary Ann Liebert]
日期:2022-08-01
卷期号:42 (8): 430-443
被引量:8
标识
DOI:10.1089/jir.2022.0036
摘要
Interferon-induced transmembrane (IFITM) proteins mediate protection against enveloped viruses by blocking membrane fusion at endosomes. IFITM1 and IFITM3 are crucial for protection against influenza, and various single nucleotide polymorphisms altering their function have been linked to disease susceptibility. However, bulk IFITM1 and IFITM3 mRNA expression dynamics and their correlation with clinical outcomes have not been extensively addressed in patients with respiratory infections. In this study, we evaluated the expression of IFITM1 and IFITM3 in peripheral leukocytes from healthy controls and individuals with severe pandemic influenza A(H1N1) or coronavirus disease 2019 (COVID-19). Comparisons between participants grouped according to their clinical characteristics, underlying disease, and outcomes showed that the downregulation of IFITM1 was a distinctive characteristic of severe pandemic influenza A(H1N1) that correlated with outcomes, including mortality. Conversely, increased IFITM3 expression was a common feature of severe pandemic influenza A(H1N1) and COVID-19. Using a high-dose murine model of infection, we confirmed not only the downregulation of IFITM1 but also of IFITM3 in the lungs of mice with severe influenza, as opposed to humans. Analyses in the comparative cohort also indicate the possible participation of IFITM3 in COVID-19. Our results add to the evidence supporting a protective function of IFITM proteins against viral respiratory infections in humans.
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