乙醇酸
乳酸
化学
高分子化学
细菌
生物
遗传学
作者
Chang‐Ming Dong,Kun‐Yuan Qiu,Zhong‐Wei Gu,Xia Feng
标识
DOI:10.1002/1099-0518(20001201)38:23<4179::aid-pola20>3.3.co;2-x
摘要
D,L-3-Methylglycolide (MG) was synthesized via two step reactions with a good yield (42%). It was successfully polymerized in bulk with stannous octoate as a catalyst at 110 °C. The effects of the polymerization time and catalyst concentration on the molecular weight and monomer conversion were studied. Poly(D,L-lactic acid-co-glycolic acid) (D,L-PLGA50; 50/50 mol/mol) copolymers were successfully synthesized from the homopolymerization of MG with high polymerization rates and high monomer conversions under moderate polymerization conditions. 1H NMR spectroscopy indicated that the bulk ring-opening polymerization of MG conformed to the coordination–insertion mechanism. 13C NMR spectra of D,L-PLGA50 copolymers obtained under different experimental conditions revealed that the copolymers had alternating structures of lactyl and glycolyl. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 4179–4184, 2000
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