Lv11
32 积分 2024-06-17 加入
Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain
2小时前
待确认
Hydrogen-Bond Donors in Drug Design
3天前
已完结
Is Target-Based Drug Discovery Efficient? Discovery and “Off-Target” Mechanisms of All Drugs
3天前
已完结
Development of Glycosylation Protocols Using Glycosyl N-Phenylethynyl Pyrrole-2-carboxylates as Donors
6天前
已完结
FDA-Approved Oximes and Their Significance in Medicinal Chemistry
7天前
已完结
Corrigendum to “structure property relationships of N-Acylsulfonamides and related bioisosteres” European journal of medicinal chemistry, 218 (2021), 113399
7天前
已完结
Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases
8天前
已完结
Discovery of a Novel Macrocyclic Noncovalent CDK7 Inhibitor for Cancer Therapy
10天前
已完结
Discovery of novel substituted (Z)-N'-hydroxy-3-(3-phenylureido)benzimidamide derivatives as multifunctional molecules targeting pathological hallmarks of Alzheimer’s disease
28天前
已完结
Discovery of a novel dual-target inhibitor of CDK12 and PARP1 that induces synthetic lethality for treatment of triple-negative breast cancer
1个月前
已完结
皖公网安备34019202002308
