Lv1
48 积分 2023-06-19 加入
Design, synthesis and biological evaluation of 3-arylisoquinoline derivatives as topoisomerase I and II dual inhibitors for the therapy of liver cancer
28天前
已完结
New pyrazole-pyridazine hybrids as selective COX-2 inhibitors: Design, synthesis, molecular docking, in silico studies and investigation of the anti-inflammatory potential by evaluation of TNF-α, IL-6, PGE-2 and NO in LPS-induced RAW264.7 macrophages
2个月前
已完结
Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
2个月前
已完结
Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles
4个月前
已关闭
Targeting glutaminase 1 (GLS1) by small molecules for anticancer therapeutics
4个月前
已完结
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling
4个月前
已完结
Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
4个月前
已完结
Discovering potential WRN inhibitors from natural product database through computational methods
4个月前
已完结
Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening
4个月前
已完结
Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts
5个月前
已完结
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