Lv7
4980 积分 2022-12-22 加入
Discovery of Highly Potent AKR1C3 Inhibitors Treating Sorafenib-Resistant Hepatocellular Carcinoma
10小时前
待确认
Metabolically Stable Anomeric Linkages Containing GalNAc–siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways
3天前
已完结
Nitroaromatic-Based Triazene Prodrugs to Target the Hypoxic Microenvironment in Glioblastoma
9天前
已完结
Biocatalytic Thionation of Epoxides for Enantioselective Synthesis of Thiiranes
18天前
已完结
First Multikilogram Synthesis of the Next-Generation Oral Selective ERα Degrader Camizestrant
23天前
已完结
Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet–Spengler Condensation
25天前
已完结
Enantioselective Formal Synthesis of (–)-Catharanthine through Enzyme-Catalyzed Desymmetrization of a meso-Azabicyclo [2.2.2]octane
25天前
已完结
Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity
1个月前
已完结
Discovery of orally bioavailable inhibitors of MALT1 with in vivo activity for psoriasis
1个月前
已完结
Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3′ End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain
1个月前
已完结
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