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勤奋世倌
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64 积分
2025-01-10 加入
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A new BRAF inhibitor breaks resistance barriers
17小时前
已完结
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Augmenting Protein Degradation Capacity of PROTAC through Energy Metabolism Regulation and Targeted Drug Delivery
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Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders
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Novel PROTACs for degradation of SHP2 protein
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A Potent SOS1 PROTAC Degrader with Synergistic Efficacy in Combination with KRASG12C Inhibitor
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Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors
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已完结
Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers
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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration
2个月前
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Targeting cancer with small-molecule pan-KRAS degraders
2个月前
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