Lv54
970 积分 2024-03-08 加入
Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of OCTs and OCTN2 at the blood-brain barrier
1小时前
求助中
Cisplatin-induced acute kidney injury increased brain 5-HT levels partly due to the hippuric acid-induced upregulation of CYP2D4 expression and function in brain of rats
3天前
待确认
Quercetin‐Driven Akkermansia Muciniphila Alleviates Obesity by Modulating Bile Acid Metabolism via an ILA/m6A/CYP8B1 Signaling
12天前
已完结
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver
3个月前
已完结
A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor-selective accumulation of 5-FU
5个月前
已完结
Investigation of 5‐FU disposition after oral administration of capecitabine, a triple‐prodrug of 5‐FU, using a physiologically based pharmacokinetic model in a human cancer xenograft model: comparison of the simulated 5‐FU exposures in the tumour tissue between human and xenograft model
5个月前
已完结
Prediction of Human Serotonin and Norepinephrine Transporter Occupancy of Duloxetine by Pharmacokinetic/Pharmacodynamic Modeling in the Rat
7个月前
已完结
Exploratory Translational Modeling Approach in Drug Development to Predict Human Brain Pharmacokinetics and Pharmacologically Relevant Clinical Doses
7个月前
已完结
Concentration-dependent plasma protein binding: Expect the unexpected
8个月前
已完结
Pharmacokinetics–Pharmacodynamics Modeling for Evaluating Drug–Drug Interactions in Polypharmacy: Development and Challenges
9个月前
已完结
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