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78 积分 2023-12-25 加入
A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine
16天前
已完结
Therapeutic exploration of biased ligands at class A G protein-coupled receptors over the past 20 years
16天前
已完结
Discovery of pan-IAP degraders via a CRBN recruiting mechanism
1个月前
已完结
E3 ubiquitin ligases and their therapeutic potential in disease Management
1个月前
已完结
RNK-05047: a chaperone-mediated protein degrader that selectively targets BRD4 while recruiting the HSP90 chaperone
1个月前
已完结
XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation
1个月前
已完结
Developments of CRBN-based PROTACs as potential therapeutic agents
1个月前
已完结
Recent advancements in the discovery of cereblon-based protease-targeted chimeras with potential for therapeutic intervention
1个月前
已完结
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases
1个月前
已完结
Gastric cancer
2个月前
已完结
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