Lv1
54 积分 2024-02-05 加入
Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer
8天前
已完结
Structure-based discovery of 1-(3-fluoro-5-(5-(3-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)phenyl)-3-(pyrimidin-5-yl)urea as a potent and selective nanomolar type-II PLK4 inhibitor
21天前
已完结
Design, synthesis, and biological evaluation of novel pyrazolo [3,4-d]pyrimidine derivatives as potent PLK4 inhibitors for the treatment of TRIM37-amplified breast cancer
21天前
已完结
The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones as Orally Bioavailable Antitumor Agents
1个月前
已完结
The Discovery of PLK4 Inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents
1个月前
已完结
The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones as Orally Bioavailable Antitumor Agents
1个月前
已完结
Discovery of CZS-241: A Potent, Selective, and Orally Available Polo-Like Kinase 4 Inhibitor for the Treatment of Chronic Myeloid Leukemia
2个月前
已完结
Product Class 17: Thiazoles
3个月前
已完结
Stearoylation cycle regulates the cell surface distribution of the PCP protein Vangl2
4个月前
已完结
Nickel-catalyzed C3-alkylation of indoles with alcohols via a borrowing hydrogen strategy
5个月前
已完结
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