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60 积分 2023-06-24 加入
Discovery of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent and Selective FGFR Inhibitors against Gatekeeper Mutants for the Treatment of NSCLC
7天前
已完结
Design, synthesis and antitumor activity of a novel FGFR2-selective degrader to overcome resistance of the FGFR2V564F gatekeeper mutation based on a pan-FGFR inhibitor
29天前
已完结
Drug-induced enzyme activity inhibition and CYP3A4 genetic polymorphism significantly shape the metabolic characteristics of furmonertinib
3个月前
已完结
Triptolide inhibits intrahepatic cholangiocarcinoma growth by suppressing glycolysis via the AKT/mTOR pathway
3个月前
已完结
Activity Variations of CYP2B6 Determine the Metabolic Stratification of Efavirenz
3个月前
已完结
Identification of Pyridinyltriazine Derivatives as Potent panFGFR Inhibitors against Gatekeeper Mutants for Overcoming Drug Resistance
3个月前
已完结
EXPRESSION, PURIFICATION, AND CHARACTERIZATION OF MOUSE CYP2D22
4个月前
已完结
The impact of CYP3A4 genetic polymorphism on crizotinib metabolism and drug-drug interactions
6个月前
已完结
ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites
6个月前
已完结
CDK4/6 Inhibitors in Breast Cancer Treatment: Potential Interactions with Drug, Gene, and Pathophysiological Conditions
7个月前
已完结
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