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36 积分 2021-08-16 加入
Discovery of a NCOA4 Degrader for Labile Iron-Dependent Ferroptosis Inhibition
7天前
已完结
Small Molecule-Drug Conjugates: An Emerging Drug Design Strategy for Targeted Therapeutics
1个月前
已完结
Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer
2个月前
已完结
Design, synthesis and antitumor activity of a novel FGFR2-selective degrader to overcome resistance of the FGFR2V564F gatekeeper mutation based on a pan-FGFR inhibitor
2个月前
已完结
NQO1-responsive Trimethyl lock benzoquinone: A cleavable linker strategy for antibody-drug conjugates
2个月前
已完结
Azobenzene‐Based Linker Strategy for Selective Activation of Antibody–Drug Conjugates
2个月前
已完结
Boosting Energy Deprivation via Synchronous Interventions of Oxidative Phosphorylation and Glycolysis for Cancer Therapy with 1,8-Naphthyridine-Piperazine-Dithiocarbamate Ruthenium(II) Polypyridyl Complexes
2个月前
已完结
Discovery of Novel and Highly Potent Dual PD-L1/Histone Deacetylase 6 Inhibitors with Favorable Pharmacokinetics for Cancer Immunotherapy
2个月前
已完结
2024 FDA approvals
2个月前
已完结
The changing landscape of medicinal chemistry optimization
3个月前
已完结
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