Lv5
1038 积分 2024-06-12 加入
A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader
3天前
已关闭
Nerandomilast, a PDE4B inhibitor, alleviates silica‐induced lung inflammation and fibrosis by inhibition of NLRP3 inflammasome and TGF‐β/Smad signalling
1个月前
已完结
A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors
2个月前
已完结
HER2-Selective and Reversible Tyrosine Kinase Inhibitor Tucatinib Potentiates the Activity of T-DM1 in Preclinical Models of HER2-positive Breast Cancer
2个月前
已完结
The evolving landscape of RAS-targeted therapies
2个月前
已完结
Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome
2个月前
已完结
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer
3个月前
已完结
GZMK+CD8+ T cells: multifaceted roles beyond cytotoxicity
3个月前
已完结
Discovery of Rigid Linker-Based IRAK4 PROTACs with Improved Metabolic Stability for the Treatment of Inflammatory Diseases
3个月前
已完结
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