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250 积分 2023-09-26 加入
Clinical Activity of CC-90009, a Cereblon E3 Ligase Modulator and First-in-Class GSPT1 Degrader, As a Single Agent in Patients with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML): First Results from a Phase I Dose-Finding Study
1天前
已完结
Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1
7天前
已完结
Selective and Potent Molecular Glue Degraders for NIMA‐related Kinase 7
1个月前
已完结
Routes to molecular glue degrader discovery
1个月前
已完结
CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML)
5个月前
已关闭
CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML)
5个月前
已关闭
Molecular glues for protein-protein interactions: Progressing toward a new dream
5个月前
已完结
Interleukin-11 drives fibroblast metabolic reprogramming in crystalline silica-induced lung fibrosis
5个月前
已完结
Abstract 2048: Discovery of induction and release of IL-1b are unique and on-target effects of GSPT1 degradation that provide potential mitigation strategies to hypotension in the CC-90009-AML-001 phase 1 trial
8个月前
已关闭
The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia
8个月前
已完结
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