Lv3
250 积分 2023-09-26 加入
Routes to molecular glue degrader discovery
1天前
已完结
CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML)
3个月前
已关闭
CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML)
3个月前
已关闭
Molecular glues for protein-protein interactions: Progressing toward a new dream
3个月前
已完结
Interleukin-11 drives fibroblast metabolic reprogramming in crystalline silica-induced lung fibrosis
4个月前
已完结
Abstract 2048: Discovery of induction and release of IL-1b are unique and on-target effects of GSPT1 degradation that provide potential mitigation strategies to hypotension in the CC-90009-AML-001 phase 1 trial
6个月前
已关闭
The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia
6个月前
已完结
Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors
6个月前
已完结
Tubuloside B, a major constituent of Cistanche deserticola, inhibits migration of hepatocellular carcinoma by inhibiting Hippo-YAP pathway
6个月前
已完结
Integrated transcriptome and in vitro analysis revealed anti-proliferative effect of sodium perborate on hepatocellular carcinoma cells
6个月前
已完结
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