Lv3
290 积分 2025-08-10 加入
Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers
2个月前
已完结
Pushing the Limits of Detection of Weak Binding Using Fragment-Based Drug Discovery: Identification of New Cyclophilin Binders
3个月前
已完结
Toward Dual Targeting of Catalytic and Gatekeeper Pockets in Cyclophilins Using a Macrocyclic Scaffold
3个月前
已完结
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A
3个月前
已完结
Rational Screening for Cooperativity in Small-Molecule Inducers of Protein–Protein Associations
7个月前
已完结
RIPTACs: A groundbreaking approach to drug discovery
7个月前
已完结
Hijacking Methyl Reader Proteins for Nuclear-Specific Protein Degradation
7个月前
已完结
Design of PROTACs utilizing the E3 ligase GID4 for targeted protein degradation
7个月前
已完结
A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1
7个月前
已完结
Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets
7个月前
已完结
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