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70 积分 2022-06-07 加入
Small Interfering RNAs Containing Dioxane- and Morpholino-Derived Nucleotide Analogues Show Improved Off-Target Profiles and Chirality-Dependent In Vivo Knock-Down
10小时前
待确认
SNA-modified antisense oligonucleotides: A new pathway for renal targeting?
1个月前
已关闭
Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo
1个月前
已完结
Amide Modifications in the Seed Region of the Guide Strand Improve the On-Target Specificity of Short Interfering RNA
5个月前
已完结
A 2′-modified uridine analog, 2′-O-(methylthiomethoxy)methyl uridine, for siRNA applications
5个月前
已完结
Synthesis, gene silencing activity, thermal stability, and serum stability of siRNA containing four (S)-5′-C-aminopropyl-2′-O-methylnucleosides (A, adenosine; U, uridine; G, guanosine; and C, cytidine)
5个月前
已完结
siRNA Seed Region Is Divided into Two Functionally Different Domains in RNA Interference in Response to 2′-OMe Modifications
5个月前
已关闭
Synthesis and characterization of novel (S)-5′-C-aminopropyl-2′-fluorouridine modified oligonucleotides as therapeutic siRNAs
5个月前
已完结
siRNA modification and delivery for drug development
5个月前
已完结
The potential role of N7-methylguanosine (m7G) in cancer
5个月前
已完结
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