Lv1
44 积分 2025-08-08 加入
Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors
1个月前
已完结
Discovery and Structure–Activity Relationship Studies of Diazepine Derivatives as a New Class of Ferroptosis Inhibitors with Potent Efficacy in the Doxorubicin-Induced Cardiomyopathy Model
1个月前
已完结
Strategic Use of Benzylic Alcohols Reveals Cryptic Hydrogen-Bonding Interactions: Discovery of HBC-12551 as a Potent Noncovalent Bruton’s Tyrosine Kinase Inhibitor
1个月前
已完结
A Targeted Covalently Activated Chemotherapy Strategy Synergistically Enhances Cytotoxicity of Ibrutinib and Selectivity of Doxorubicin to B-cell Lymphoma Cells
1个月前
已完结
Discovery of a Highly Potent and Selective Small-Molecule Inhibitor of In Vivo Anaerobic Choline Metabolism by Human Gut Bacteria
1个月前
已完结
Discovery of Potent, Selective, and Brain-Penetrant Small Molecule CD38 Inhibitors
1个月前
已完结
Discovery of Highly Selective AKR1C3 Inhibitors to Overcome EGFR C797S-Mediated Osimertinib Resistance in Non-Small Cell Lung Cancer
1个月前
已完结
Discovery of Tertiary Benzenesulfonanilide Chemotypes as HDAC Inhibitors via Multistrategy In Silico and Biological Evaluation for Colon Cancer Therapy
1个月前
已完结
Design, Synthesis, and Pharmacological Evaluation of Metabolically Stable Apelin Receptor Antagonists with Improved In Vivo Exposure and Efficacy in Ovarian Cancer
1个月前
已完结
Targeting thymine DNA glycosylase induces synthetic lethality in p53-deficient cancers
2个月前
已完结
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