Lv5
1065 积分 2021-08-17 加入
Linker-rigidified VHL homodimerizers convert degraders into stabilizers of non-ubiquitinable ternary complexes
8天前
已关闭
ICH S7B In Vitro Assays Do Not Address Mechanisms of QTC Prolongation for Peptides and Proteins – Data in Support of Not Needing Dedicated QTC Studies
3个月前
已完结
Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases
3个月前
已完结
On the relationship between hERG inhibition and the magnitude of QTc prolongation: An in vitro to clinical translational analysis
3个月前
已完结
AI-Validated Brain Targeted mRNA Lipid Nanoparticles with Neuronal Tropism
4个月前
已完结
Drug and pro-drug substrates and pseudo-substrates of human butyrylcholinesterase
5个月前
已完结
A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors
5个月前
已完结
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2
5个月前
已完结
A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models
5个月前
已完结
Status of Acetylcholinesterase and Butyrylcholinesterase in Alzheimer's Disease and Type 2 Diabetes Mellitus
5个月前
已完结
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