Lv21
120 积分 2021-08-05 加入
The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines
4个月前
已完结
A Scale of Agonism and Allosteric Modulation for Assessment of Selectivity, Bias, and Receptor Mutation
5个月前
已完结
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain
7个月前
已完结
Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain
8个月前
已完结
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer
3年前
已完结
Therapeutic inhibition of HIF2α reverses polycythemia and pulmonary hypertension in murine models of two human diseases
3年前
已完结
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