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Growing Tumor Spheroids from Blood: A Breakthrough Platform for Dynamic DrugSurveillance and Prognostic Evaluation
从血液中生长肿瘤球体:动态药物监测和预后评估的突破性平台
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MD Pegram, YC Chang, WH Kuo, Y Zong… - … Journal of Cancer …, 2023 - scholar.archive.org We have established a single cell derived 3D organoid culture platform,“Rapid, Reproducible, Rare Cell 3D Expansion”(R3CE). This is the first scaffold-free 3D culture system that does not require cell aggregation or 3D scaffold such as Matrigel. We have demonstrated its ability not only to generate 3D organoids of solid tumors and normal tissues from surgical tissues, but also 3D organoids from rare cells such as needle biopsies and circulating tumor cells (CTCs) from peripheral blood with 96% successful rate |
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