| 标题 |
[Chemical structure and biosynthesis of lipopolysaccharide--important component of the cell envelope of Gram-negative bacteria]
[脂多糖的化学结构和生物合成——革兰氏阴性菌细胞膜的重要成分]
相关领域
单元格信封
脂多糖
脂质A
细菌外膜
细菌
革兰氏阴性菌
细胞壁
细菌细胞结构
化学
生物合成
生物化学
细胞生物学
微生物学
生物
大肠杆菌
酶
免疫学
基因
遗传学
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| 其它 |
Abstract The outer membrane is the first layer of the cell envelope of Gram-negative bacteria. This fragment of the cell envelope is built of phospholipids in the internal part and mainly of lipopolysaccharides in the external part. Lipopolysaccharide (LPS, endotoxin) is a thermostabile component consisting of three parts which differ in chemical structure and biological activity. LPS contributes greatly to the structural integrity of bacteria and protects them from host immune defenses. This review explains what makes this LPS leaflet an effective barrier to permeability and describes the pathways of biosynthesis and the assembly of the hydrophobic domain, known as lipid A, a core oligosaccharide, and the distal polysaccharide (O-antigen). PubMed Disclaimer |
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