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Pathological angiogenesis of tumors impairs oxygen delivery, changes metabolic pathways, and leads to hypoxia, acidity and high interstitial fluid pressure in the TME, which is conducive to tumor progression, metastasis and drug resistance
肿瘤病理性血管生成损害氧输送,改变代谢途径,导致TME缺氧、酸性和高间质液压力,有利于肿瘤进展、转移和耐药
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