| 标题 |
LONG-TERM DOUBLE-BLIND-STUDY ON THE INFLUENCE OF DIETARY-FIBERS ON FECAL BILE-ACID EXCRETION IN JUVENILE ULCERATIVE-COLITIS
膳食纤维对青少年溃疡性结肠炎粪便胆汁酸排泄影响的长期双盲研究
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| 其它 | A double-blind cross-over long-term trial (18 months) with randomized supplementation with wheat fibre or ispaghula for two periods of six months, separated by a six-month wash-out period with placebo, was performed in ten patients with juvenile ulcerative colitis to study the effect on faecal bile acid (BA) excretion. All patients were in remission since 0.5-2 years and orally treated with sulphasalazine. The average intake of either fibres was 16 g day-1. Faecal samples were collected (72 h) before and after each fibre period. Faecal water were prepared by centrifugation of faeces at 15 000 g for 2 h. BA in faeces and faecal water were studied using capillary column gas-liquid chromatography-mass spectrometry. |
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