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Therapeutic effects of freeze-dried jaboticaba powder in ulcerative colitis: a randomized, double-blind, placebo-controlled clinical trial
加博替卡巴冻干粉治疗溃疡性结肠炎的随机、双盲、安慰剂对照临床试验
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作者：N. Raquel Franco Leal; Roberto de Paula do 发布年份：2024 摘要：Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that has no cure and generates a persistent inflammatory process in the mucosa of the rectum and colon, producing gastrointestinal symptoms and decreasing the quality of life of the patient. As far as the etiology and progression of the disease, the following factors are involved: defects in the epithelial barrier integrity, infiltration of neutrophils and lymphocytes, exacerbated production of cytokines, dysfunctions in nuclear transcription factors, and intestinal dysbiosis. It is estimated that by 2030, the prevalence of IBDs will grow by 5% per year, a scenario said to be capable of impacting health systems, overloading workforces and increasing treatment costs. |
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