| 标题 |
专利、报告等 T cell receptors
T细胞受体
|
| 网址 |
求助人暂未提供
|
| DOI |
暂未提供，该求助的时间将会延长，查看原因？
|
| 其它 |
申请(专利)号：WO2017GB50985 申请日期：2017-04-07 公开/公告号：WO2017175006A1 公开/公告日期：2017-10-12 申请(专利权)人：IMMUNOCORE LIMITED 发明人：M Tara，Y Li 摘要：The present invention relates to T cell receptors (TCRs) which bind the HLA-A*02 restricted peptide SLYNTVATL (SEQ ID NO: 1) derived from the HIV Gag gene product, p17. Said TCRs comprise non-natural mutations within the alpha and/or beta variable domains relative to a native HIV TCR. The TCRs of the invention possess unexpectedly high affinity, specificity and sensitivity for a complex of SEQ ID NO: 1 and HLA-A*02, and drive a particularly potent T cell response. Such TCRs are particularly useful in the development of soluble immunotherapeutic reagents for the treatment of HIV infected individuals |
| 求助人 | |
| 下载 |
lalala
SYLH
劲秉
杳鸢
迟大猫
kingwill
djsj
36456657
坚强的广山
子车茗
笑点解析
凹凸先森
Hungrylunch
pluto
天真蓝
prosperp
眯眯眼的衬衫
宜醉宜游宜睡
爱静静
VDC
皖公网安备34019202002308
