| 标题 |
 Metronidazole- and Amoxicillin-Loaded PLGA and PCL Nanofibers as Potential Drug Delivery Systems for the Treatment of Periodontitis: In Vitro and In Vivo Evaluations 载甲硝唑和阿莫西林的PLGA和PCL纳米纤维作为治疗牙周炎的潜在药物传递系统：体外和体内评价
相关领域
纳米纤维
PLGA公司
静电纺丝
体内
药物输送
甲硝唑
生物医学工程
牙周炎
己内酯
药品
阿莫西林
药理学
材料科学
体外
化学
抗生素
牙科
纳米技术
医学
生物化学
生物技术
生物
有机化学
共聚物
聚合物
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| 其它 | The purpose of this study was to prepare poly (D-L) lactide-co-glycolide (PLGA) and poly ε-caprolactone (PCL) nanofibers containing metronidazole and amoxicillin using an electrospinning process as intrapocket sustained-release drug delivery systems for the treatment of periodontal diseases. Scanning electron microscopy showed that the drug containing PLGA and PCL nanofibers produced from the electrospinning process was uniform and bead-free in morphology. The obtained nanofibers had a strong structure and resisted external tension according to the tensiometry results. The cytotoxicity results indicated acceptable cell viability (>80%). Quantification by high-performance liquid chromatography showed almost complete in vi |
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