| 标题 |
How Mechanical Properties of the Pancreas Signal the Immune System in Type 1 Diabetes
1型糖尿病患者胰腺的机械特性如何向免疫系统发出信号
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| 其它 | The goal of this work is to investigate the role of mechanobiology in type 1 diabetes (T1D) using hyaluronic acid (HA)-based hydrogels that mimic the physiological mechanics and biophysical cues in pancreatic islets. This thesis shows each stage of the research, which focuses on characterizing the mechanical properties of the pancreatic islet matrix and the recapitulation of these properties through in-depth in vitro experiments to study their influence on T cell function. The thesis begins with a review in chapter 2 discussing the current challenges in the field of T cell mechanobiology and the importance of elucidating the field by using bioengineering strategies that can dissect the role of mechanical cues on T cell function and behavior while keeping the experimental set-up physiologically relevant. |
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