| 标题 |
 The role of oxidative stress in the ochratoxin A-mediated toxicity in proximal tubular cells 相关领域
氧化应激
赭曲霉毒素A
谷胱甘肽
毒性
活性氧
细胞毒性
化学
赭曲霉毒素
药理学
抗氧化剂
生物化学
真菌毒素
生物
体外
食品科学
酶
有机化学
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| 网址 | |
| DOI | |
| 其它 | Balkan endemic nephropathy (BEN), a disease characterized by progressive renal fibrosis in human patients, has been associated with exposure to ochratoxin A (OTA). This mycotoxin is a frequent contaminant of human and animal food products, and is toxic to all animal species tested. OTA predominantly affects the kidney and is known to accumulate in the proximal tubule (PT). The induction of oxidative stress is implicated in the toxicity of this mycotoxin. In the present study, primary rat PT cells and LLC-PK(1) cells, which express characteristics of the PT, were used to investigate the OTA-mediated oxidative stress response. OTA exposure of these cells resulted in a concentration-dependent elevation of reactive oxygen species (ROS) levels, depletion of cellular glutathione (GSH) levels and an increase in the formation of 8-oxoguanine. |
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