| 标题 |
 Convenient tumor 3D spheroid arrays manufacturing via acoustic excited bubbles for in situ drug screening |
| 网址 | |
| DOI | |
| 其它 |
摘要 The quick and convenient fabrication of in vitro tumor spheroids models has been pursued for clinical drug discovery and personalized therapy. Here, uniform three-dimensional (3D) tumor spheroids are quickly constructed by acoustically excited bubble arrays in a microfluidic chip and performed drug response testing in situ. In detail, bubble oscillation excited by acoustic waves induces second radiation force, resulting in the cells rotating and aggregating into tumor spheroids, which obtain controllable sizes ranging from 30 to 300 μm. |
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