| 标题 |
 Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery 用于靶向蛋白质降解的分子胶：从偶然发现到理性发现
相关领域
偶然性
化学
药物发现
计算生物学
合理设计
蛋白质水解
蛋白质降解
生物化学
纳米技术
生物
酶
哲学
材料科学
认识论
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| 网址 | |
| DOI | |
| 其它 | Targeted protein degradation is a promising area in the discovery and development of innovative therapeutics. Molecular glues mediate proximity-induced protein degradation and have intrinsic advantages over heterobifunctional proteolysis-targeting chimeras, including unprecedented mechanisms, distinct biological activities, and favorable physicochemical properties. Classical molecular glue degraders have been identified serendipitously, but rational discovery and design strategies are emerging rapidly. In this review, we aim to highlight the recent advances in molecular glues for targeted protein degradation and discuss the challenges in developing molecular glues into therapeutic agents. In particular, discovery strategies, action mechanisms, and representative case studies will be addressed. |
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