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Lack of an independent relationship between CXCL16 gene rs2277680 polymorphism and instability of carotid plaque in the Chinese Han population
中国汉族人群CXCL16基因rs2277680多态性与颈动脉斑块不稳定性缺乏独立关系
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International Journal of Clinical and Experimental Medicine 2016 Vol. 9 Issue 3 Pages 6693-6698 https://www-embase-com-443.webvpn.cams.cn/search/results?subaction=viewrecord&id=L610014643&from=export Background: Chemokine CXC ligand 16 (CXCL16) may have an important role in the development of vulnerable carotid plaques. The rs2277680 polymorphism located in exon 4 of CXCL16 has been shown to accelerate inflammation, which increases the instability of carotid plaques. The aim of this study was to investigate the association between the CXCL16 gene rs2277680 polymorphism and the instability of carotid plaques in the Chinese Han population. Methods: For this study, 554 patients were enrolled and divided into three groups according to the results of carotid ultrasound examination: vulnerable plaque group (n = 129), stable plaque group (n = 189) and no plaque group (n = 236) |
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