表型
结直肠癌
生物
病理
肿瘤坏死因子α
Fas受体
癌症研究
癌症
淋巴细胞
坏死
中性粒细胞与淋巴细胞比率
渗透(HVAC)
免疫学
细胞凋亡
医学
程序性细胞死亡
基因
遗传学
生物化学
物理
热力学
作者
Eduardo Vadillo,Alejandra Mantilla,Cristina Aguilar-Flores,Saraí G. De León-Rodríguez,Sandra Vela-Patiño,Juan Badillo,Keiko Taniguchi‐Ponciano,Daniel Marrero–Rodríguez,Lourdes Ramírez,Iliana I. León-Vega,Carmen Fuentes-Castañeda,Patricia Piña‐Sánchez,Jessica L. Prieto-Chávez,Vadim Pérez‐Koldenkova,Juan José Montesinos,Laura C. Bonifaz,Rosana Pelayo,Héctor Mayani,Michael Schnoor
标识
DOI:10.1093/jleuko/qiad123
摘要
Abstract Neutrophils infiltrate several types of cancer; however, whether their presence is associated with disease progression remains controversial. Here, we show that colon tumors overexpress neutrophil chemoattractants compared to healthy tissues, leading to their recruitment to the invasive margin and the central part of colon tumors. Of note, tumor-associated neutrophils expressing tumor necrosis factor α, which usually represents an antitumoral phenotype, were predominantly located in the invasive margin. Tumor-associated neutrophils from the invasive margin displayed an antitumoral phenotype with higher ICAM-1 and CD95 expression than neutrophils from healthy adjacent tissues. A higher neutrophil/lymphocyte ratio was found at later stages compared to the early phases of colon cancer. A neutrophil/lymphocyte ratio ≤3.5 predicted tumor samples had significantly more neutrophils at the invasive margin and the central part. Moreover, tumor-associated neutrophils at the invasive margin of early-stage tumors showed higher ICAM-1 and CD95 expression. Coculture of colon cancer cell lines with primary neutrophils induced ICAM-1 and CD95 expression, confirming our in situ findings. Thus, our data demonstrate that tumor-associated neutrophils with an antitumoral phenotype characterized by high ICAM-1 and CD95 expression infiltrate the invasive margin of early-stage colon tumors, suggesting that these cells can combat the disease at its early courses. The presence of tumor-associated neutrophils with antitumoral phenotype could help predict outcomes of patients with colon cancer.
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