生物传感器
碳纳米管
材料科学
原子层沉积
纳米技术
场效应晶体管
生物分子
检出限
碳纳米管场效应晶体管
晶体管
光电子学
图层(电子)
化学
电气工程
电压
工程类
色谱法
作者
Youqiang Xing,Jiaqi Hu,Ze Wu,Peng Huang,Bingjue Li,Lei Liu
出处
期刊:Carbon
[Elsevier]
日期:2024-04-01
卷期号:223: 119022-119022
被引量:1
标识
DOI:10.1016/j.carbon.2024.119022
摘要
MicroRNAs (miRNAs) act as diagnostic markers for various diseases, and achieving ultra-sensitive detection of miRNAs has an important effect on early disease diagnosis. Field-effect transistor (FET) biosensor exhibits superior sensitivity compared to conventional clinical detection instruments in detecting biomolecules. However, developing high-sensitive FET biosensors for detecting microRNAs remains challenging. In this study, we developed a FET biosensor using MoS2 and a network film of semiconductor single-walled carbon nanotube (SWCNT) as channel materials. The MoS2 cycles were precisely controlled and optimized by atom layer deposition (ALD), and the optimized 3-cycle device exhibited the best performance. This adjustment is beneficial for enhancing the charge transfer between SWCNT and MoS2, as well as improving the on/off ratio and mobility of FET devices. Additionally, the SWCNT@MoS2 structure offers a larger specific surface area, providing more active binding sites on the sensing interface. These two favorable factors contribute to the realization of linear detection miRNA-21 from 1 × 10−17 to 1 × 10−10 mol L−1 in biosensors. The theoretical detection limit of the biosensor is 1.9 × 10−18 mol L−1. This work develops a novel approach to achieve highly sensitive detection of miRNA for high-performance FET biosensors.
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