淀粉样变性
淀粉样蛋白(真菌学)
纳米技术
淀粉样疾病
疾病
计算生物学
医学
计算机科学
神经科学
淀粉样纤维
材料科学
淀粉样β
生物
病理
作者
José P. Leite,Flávio Figueira,Ricardo F. Mendes,Filipe A. Almeida Paz,Luı́s Gales
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2023-03-09
卷期号:8 (3): 1033-1053
被引量:14
标识
DOI:10.1021/acssensors.2c02741
摘要
Metal-organic frameworks (MOFs) are versatile compounds with emergent applications in the fabrication of biosensors for amyloid diseases. They hold great potential in biospecimen protection and unprecedented probing capabilities for optical and redox receptors. In this Review, we summarize the main methodologies employed in the fabrication of MOF-based sensors for amyloid diseases and collect all available data in the literature related to their performance (detection range, limit of detection, recovery, time of analysis, among other parameters). Nowadays, MOF sensors have evolved to a point where they can, in some cases, outperform technologies employed in the detection of several amyloid biomarkers (amyloid β peptide, α-synuclein, insulin, procalcitonin, and prolactin) present in biological fluids, such as cerebrospinal fluid and blood. A special emphasis has been given by researchers on Alzheimer's disease monitoring to the detriment of other amyloidosis that are underexploited despite their societal relevance (e.g., Parkinson's disease). There are still important obstacles to overcome in order to selectively detect the various peptide isoforms and soluble amyloid species associated with Alzheimer's disease. Furthermore, MOF contrast agents for imaging peptide soluble oligomers in living humans are also scarce (if not nonexistent), and action in this direction is unquestionably required to clarify the contentious link between the amyloidogenic species and the disease, guiding research toward the most promising therapeutic strategies.
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