PROFILING METHYLATION IN PRIMARY OSTEOARTHRITIS CARTILAGE

Purpose (the aim of the study): Osteoarthritis is a complex joint disease that affects more than 300 million people worldwide, with higher prevalence and greater disease severity in women. To promote the development of novel, personalised treatment strategies, it is important to extend our knowledge about the genetic and genomic basis of osteoarthritis. Here, we aimed to identify and characterise epigenetic markers of osteoarthritis progression in a common as well as sex-specific manner and reveal sex similarities and differences.