脂质代谢
泛素
生物
分解代谢
生物化学
新陈代谢
泛素蛋白连接酶类
细胞生物学
泛素连接酶
基因
作者
Yuanming Zou,Ying Zhang,Mohan Li,Kexin Cao,Chunyu Song,Zhaobo Zhang,Kexin Cai,Danxi Geng,Shuxian Chen,Yanjiao Wu,Naijin Zhang,Guozhe Sun,Jing Wang,Yixiao Zhang,Yingxian Sun
标识
DOI:10.1016/j.ijbiomac.2024.130961
摘要
Previous studies have progressively elucidated the involvement of E3 ubiquitin (Ub) ligases in regulating lipid metabolism. Ubiquitination, facilitated by E3 Ub ligases, modifies critical enzymes in lipid metabolism, enabling them to respond to specific signals. In this review, we aim to present a comprehensive analysis of the role of E3 Ub ligases in lipid metabolism, which includes lipid synthesis and lipolysis, and their influence on cellular lipid homeostasis through the modulation of lipid uptake and efflux. Furthermore, it explores how the ubiquitination process governs the degradation or activation of pivotal enzymes, thereby regulating lipid metabolism at the transcriptional level. Perturbations in lipid metabolism have been implicated in various diseases, including hepatic lipid metabolism disorders, atherosclerosis, diabetes, and cancer. Therefore, this review focuses on the association between E3 Ub ligases and lipid metabolism in lipid-related diseases, highlighting enzymes critically involved in lipid synthesis and catabolism, transcriptional regulators, lipid uptake translocators, and transporters. Overall, this review aims to identify gaps in current knowledge, highlight areas requiring further research, offer potential targeted therapeutic approaches, and provide a comprehensive outlook on clinical conditions associated with lipid metabolic diseases.
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